Details

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• Registration Number: MAL06121092AZ

• Manufacturer: Orient Europharma Co., Ltd.

Content

• Active Ingredients: Each tablet contains 500 mg of Metformin Hydrochloride and 5 mg of Glibenclamide.

• Manufacturer: Orient Europharma Co. Ltd.

• Registration: Approved in Malaysia under the registration number MAL06121092AZ.

Indications

• Type 2 Diabetes Mellitus:

  • As an initial therapy alongside diet and exercise to improve glycemic control.

  • As a second-line therapy when diet, exercise, and initial treatment with a sulfonylurea or metformin alone do not result in adequate glycemic control.

Instructions for Use

• Dosage:

  • Starting Dose: 250 mg/1.25 mg once or twice daily with meals.

  • Maximum Dose: 2000 mg of metformin and 20 mg of glibenclamide per day.

  • Administration: Take with meals to reduce gastrointestinal side effects and to minimize the risk of hypoglycemia.

  • Titration: Increase the dose gradually based on blood glucose response and tolerability.

• Precautions:

  • Not recommended for patients with severe renal impairment, lactic acidosis, or ketoacidosis.

  • Use with caution in patients with liver disease.

  • Regular monitoring of blood glucose and renal function is advised.

  • Avoid alcohol consumption as it may increase the risk of lactic acidosis.