Details

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Ingredients, MAL, Manufacturer

• Active Ingredients: Each tablet contains 24.3 mg sacubitril and 25.7 mg valsartan (as sacubitril/valsartan sodium salt complex).

• Marketing Authorisation (MAL): MAL15125061ARZ

• Manufacturer: Novartis Sağlık Gıda ve Tarım Ürünleri Sanayi ve Ticaret A.Ş., Turkey

Content

• Active Ingredients per Tablet:

  • Sacubitril: 24.3 mg

  • Valsartan: 25.7 mg

• Formulation: Film-coated tablet for oral administration.

• Pack Size: 30 tablets per pack.

Indications

Entresto is indicated for:

• Chronic Heart Failure: To reduce the risk of cardiovascular death and hospitalization due to heart failure in adult patients with chronic heart failure and reduced ejection fraction.

• Hypertension: As an adjunctive treatment for essential hypertension in adults.

Note: Entresto is not recommended for use in children under 18 years of age.

Instructions

Dosage:

• Starting Dose: One tablet of 50 mg (24.3 mg sacubitril / 25.7 mg valsartan) taken twice daily.

• Titration: The dose may be increased to one tablet of 100 mg (48.6 mg sacubitril / 51.4 mg valsartan) taken twice daily after 2–4 weeks, based on patient tolerance.

• Renal Impairment: For patients with moderate renal impairment (eGFR 30–60 mL/min/1.73 m²), a starting dose of 50 mg twice daily is recommended.

Administration:

• Take the tablet orally with or without food.

• Swallow the tablet whole; do not split or crush.

Missed Dose:

• If a dose is missed, take it as soon as you remember.

• If it's almost time for your next dose, skip the missed dose.

• Do not take two doses at the same time to make up for a missed dose.

Storage:

• Store at room temperature, away from moisture and heat.

• Keep out of reach of children.