Details

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Manufacturer:
- Les Laboratoires Servier Industrie, France
 

Content

• Formulation: Each tablet contains 5 mg of ivabradine as the hydrochloride salt.

• Appearance: Salmon-coloured, oblong, film-coated tablet scored on both sides, engraved with “5” on one face.

• Inactive Ingredients: Lactose monohydrate, magnesium stearate, maize starch, maltodextrin, colloidal anhydrous silica, hypromellose, titanium dioxide (E171), macrogol 6000, glycerol, yellow iron oxide (E172), red iron oxide (E172). 

Indications

Coralan 5mg is indicated for:

• Chronic Stable Angina Pectoris: Symptomatic treatment in adults with normal sinus rhythm and heart rate ≥70 bpm, who are unable to tolerate or have contraindications to β-blockers, or in combination with β-blockers in patients inadequately controlled with optimal β-blocker dose.

• Chronic Heart Failure: In patients with NYHA class II to IV, systolic dysfunction, sinus rhythm, and heart rate ≥75 bpm, in combination with standard therapy including β-blocker therapy, or when β-blocker therapy is contraindicated or not tolerated. 

 Instructions

• Administration: Oral use only. Swallow the tablet whole with water. Do not chew, crush, or break the tablet.

• Dosage:

  • Chronic Stable Angina Pectoris: Initially, 5 mg twice daily. After 3–4 weeks, may increase to 7.5 mg twice daily if resting heart rate remains above 60 bpm and the initial dose is well tolerated.

  • Chronic Heart Failure: Initially, 5 mg twice daily. After 2 weeks, may increase to 7.5 mg twice daily if resting heart rate is persistently above 60 bpm. If heart rate is between 50–60 bpm, maintain 5 mg twice daily. If heart rate is below 50 bpm or symptoms related to bradycardia occur, reduce dose to 2.5 mg twice daily.

• Precautions: Monitor heart rate regularly. If heart rate decreases below 50 bpm or symptoms of bradycardia occur, reduce dose or discontinue treatment.

• Storage: Store below 30°C, in the original package to protect from moisture. Keep out of reach of children.