Details

---

Manufacturer
sanofi-aventis Sp.z.o.o.
 
Contents
Simvastatin
 
Indication
Cardiovascular risk reduction, Hyperlipidaemias.
 
Instruction
May be taken with or without food. Take in the evening. Avoid excessive consumption (>1 L/day) of grapefruit juice.
 
Drug interaction
May increase bleeding risk w/ anticoagulants. Reduced serum levels w/ bosentan, efavirenz and rifampicin. Increased risk of myopathy and rhabdomyolysis w/ colchicine, amiodarone, verapamil and diltiazem. Increased risk of myopathy w/ amlodipine, fusidic acid. Potential reduction of cytotoxic effect of rituximab. Increased hepatotoxicity w/ ezetimibe.Potentially Fatal: Concurrent use w/ itraconazole, ketoconazole, posaconazole, clarithromycin, erythromycin, telithromycin, nefazodone, niacin, HIV protease inhibitors (e.g. nelfinavir), boceprivir, telaprevir, gemfibrozil, ciclosporin and danazol may increase the risk of myopathy, rhabdomyolysis and acute renal failure.