Details

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Manufacturer
NOVARTIS PHARMA STEIN AG
 
Contents
Everolimus
 
Indication
Advanced renal cell carcinoma
 
Instruction
May be taken with or without food. Take consistently either always w/ or always w/o meals. Swallow whole do not chew/crush. For patients w/ swallowing difficulties, disperse tab in approx 30 mL of water by gently stirring immediately prior to drinking. Rinse the glass w/ the same amount of water & drink the rinse completely. Avoid grapefruit juice.
 
Drug interaction
Increased concentration with CYP3A4 inhibitors and p-glycoprotein inhibitors, e.g. ketoconazole, erythromycin, verapamil, diltiazem, ritonavir. Avoid concomitant use with strong or moderate CYP3A4 inhibitors. Coadministration with CYP3A4 inducers e.g. rifampicin, dexamethasone, phenytoin, phenobarbital may reduce exposure of Everolimus; dose increase of Everolimus may be considered if concomitant use is required.