Details

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Manufacturer
Xepa-Soul Pattinson (Malaysia) Sdn. Bhd.

Registraction Number ​​​​​
MAL19860164AZ

 

Contents

• Active Ingredient: Each film-coated tablet contains 5 mg bisoprolol fumarate, a cardioselective β₁‑blocker that reduces heart rate and blood pressure.

Indications

Used in adults for:

• Hypertension (high blood pressure)
• Stable chronic angina pectoris (chest pain due to heart disease)
• Chronic heart failure—as part of combination therapy (with ACE inhibitors, diuretics, and possibly cardiac glycosides)

Instructions for Use

• Dosage:
  • Initial: Start at 5 mg once daily, typically in the morning.
  • Usual maintenance: Up to 10 mg once daily, with a maximum of 20 mg/day, depending on tolerance and response. 
• Administration: Swallow tablet whole with water, with or without food, preferably in the morning. Do not crush or chew. 
• Special Precautions:
  • Renal/hepatic impairment: Patients with severe renal impairment (CrCl < 20 mL/min) should not exceed 10 mg/day; monitor closely. 
  • Heart failure initiation: Start at low dose and titrate gradually under supervision due to risk of transient worsening, hypotension, or bradycardia. 
  • Discontinuation: Do not stop abruptly—taper off slowly to avoid rebound cardiovascular effects.