Details

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Manufacturer
Sun Pharmaceutical Industries Limited
 
Contents
EZETIMIBE; SIMVASTATIN
 
Indication
Hypercholesterolaemia, Hyperlipidaemias, Hypertriglyceridaemia, Hyperlipoproteinaemia
 
Instruction
May be taken with or without food. Avoid excessive consumption (>1 L/day) of grapefruit juice.
 
Drug interaction
Simvastatin may cause slight elevation of serum digoxin. Cholestyramine and colestipol increase bioavailability of simvastatin. Increase in ezetimibe plasma levels with ciclosporin. Increased risk of myopathy when used with ciclosporin, gemfibrozil, danazol, amiodarone and verapamil.
Potentially Fatal: Concurrent use with itraconazole, ketoconazole, niacin, telithromycin, clarithromycin, erythromycin, nefazodone and HIV protease inhibitors may increase the risk of rhabdomyolysis and acute renal failure. Increased risk of hemorrhage with anticoagulants.