Details

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Manufacturer

- DKSH Malaysia Sdn. Bhd.

Registraction Number

- MAL19984318AZ 

Content

- Acyclovir
 

Indications

Based on Malaysian SPC and product leaflets , Acyclovir 400 STADA is indicated for:

• Treatment of varicella-zoster virus infections, including chickenpox (varicella) and shingles (herpes zoster).

• Treatment and prevention/suppressive therapy of herpes simplex virus infections involving skin and mucous membranes (e.g., genital herpes).

• Prophylaxis in severely immunocompromised adults at high risk of HSV complications
   

  Instructions

  Based on official leaflets and clinical guidelines 

• How to take

  • Oral administration, swallow whole with water. May be taken with or without food.

  • Drink plenty of fluids to support kidney function.

• Typical dosing regimens:

  • Herpes simplex (ordinary adult dose): 200 mg five times daily (~every 4 hrs) for 5–10 days.

  • Immunocompromised or poor absorption: 400 mg five times daily for 5 days.

  • Suppressive therapy (frequent recurrences): 200–400 mg, 3–4 times daily (often continuous).

  • Chickenpox (in adults or children >6 yrs): 800 mg four times daily for ~7 days (note: requires two tablets per dose).

  • Shingles: 800 mg five times daily for 7–10 days (two tablets per dose). 

• Missed dose

  • Take as soon as remembered; if near next dose, skip—do not double-dose.

• Missed or interrupted therapy

  • Complete full course, even if symptoms improve, to minimize resistance risk.

• Interactions & Precautions

  • Use with probenecid may raise acyclovir blood levels.

  • Monitor renal function—maintain hydration to avoid nephrotoxicity/crystalluria.

  • Caution in patients with severe renal impairment or low urine output (<100 mL/24 h). Avoid if urine flow severely reduced.

• Special populations

  • Breastfeeding: use discouraged as acyclovir passes into breast milk.

  • Children: dosing based on weight and age; refer to paediatric guidance.

  • Generally considered safe in pregnancy when needed.

• Storage

  • Keep below 25 °C, in original packaging, out of reach of children.