Details

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Manufacturer
MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.
 
Contents
Clozapine
 
Indication
Schizophrenia, Psychoses in Parkinson's disease, Suicidal behaviour in schizophrenia
 
Instruction
May be taken with or without food.
 
Drug interaction
Enhances the CNS effects of narcotics, antihistamines and benzodiazepines. May reduce therapeutic effect of norepinephrine. Increased plasma level with CYP1A2 inhibitors (e.g. ciprofloxacin, fluvoxamine, enoxacin, oral contraceptives, caffeine). Decreased plasma level with CYP1A2 inducers. Increased risk of neuroleptic malignant syndrome with lithium. Risk of seizures with valproic acid.Potentially Fatal: Increased risk of myelosuppression with long-acting depot antipsychotics.